Northern Regional Hospital is located at 830 Rockford Street in Mount Airy, North Carolina.

Hospital entrances are located on Rockford Street, S. South Streets, and Worth Street. Parking is free for all patients, visitors, and staff. Designated parking areas for patients and visitors are located around the campus. Handicap Parking is available in front of the Main Entrance, Surgery Center Center (lower level), and Emergency Department Entrance (Worth Street).